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               首頁(yè) >> 資源庫 >> 中文 >> 專(zhuān)家人才
            
                
            

                
            專(zhuān)家人才
            

                
            
                    
            
                        
              
                            
            • 姓名： 李尹雄
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            • 性別： 男
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            • 職稱(chēng)： 研究員
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            • 學(xué)歷： 博士
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            • 電話(huà)： 
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            • 傳真： 
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            • 電子郵件: li_yinxiong@gibh.ac.cn
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            • 通訊地址 廣州市科學(xué)城開(kāi)源大道190號
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              簡(jiǎn)歷：
              
                            
            • 1979-1985  中南大學(xué)湘雅醫學(xué)院 醫學(xué)學(xué)士
              

              1987-1991  協(xié)和醫科大學(xué) 醫學(xué)哲學(xué)博士
              

              1985-1987  中國醫學(xué)科學(xué)院基礎所助理研究員
              

              1991-1992  中國協(xié)和醫科大學(xué)助理教授
              

              1992-1993  Vanderbilt 大學(xué)醫學(xué)院細胞生物學(xué) 博士后
              

              1993-2001  Medical College of Georgia博士后
              

              2001-2010  Duke大學(xué)醫學(xué)院，終身制助教授
              

              2010-2011  南卡羅蘭拉醫科大學(xué)副教授
              

              2011-2012  首席技術(shù)官/副總裁 ，SMT 公司
              

              2012-今    中國科學(xué)院廣州生物醫藥與健康研究院，研究員，公共健康所所長(cháng)
              

              

              國家科技重大專(zhuān)項 973 “干細胞治療重大疾病機理研究” 首席科學(xué)家
              

              

               
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              研究領(lǐng)域：
              
                            
            •  · 肝臟發(fā)育和成體肝臟干細胞的分子調控機理研究；

              · 環(huán)境因素及酒精的先天致畸原理和預防研究；
              

              · 組織修復，纖維化及成體干細胞功能的調控探討；
              

              · 人群中膽固醇狀況，Hedgehog信息通路與成體干細胞健康和老化研究
              

              ·  生物標志物篩選和疾病基因診斷的研發(fā)
              

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              承擔科研項目情況：
              
                            
            • 1. Shaoyang Zhao, Jianhong Xia, Xiuhua Wu, Leilei Zhang, Pengtao Wang, Haiyun Wang, Heying Li, Xiaoshan Wang, Yan Chen, Jean Agnetti, Yinxiong Li, Duanqing Pei & Xiaodong Shu (2018) Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish Nature Communications. 9, 2639 
              

               2. Xu, G., Guo, D., Wu, F., Lai, K., Yuan, F., Liu, Y., Zhuang, Y., Wu, Y., Xu, Y., Chen, Y., Yang, F., You, K., Pan, T., Abbas, N. & Li, Y.-x. (2017) Generation of a GDE Heterozygous Mutation Human Embryonic Stem Cell Line WAe001-A-14 by CRISPR/Cas9 Editing, Stem Cell Research. 27:38-41.
              

              3. Yuan, F., Guo, D., Liu, Y., Xu, Y., Gao, G., Wu, Y., Yang, F., Ke, X., Lai, K., Wei, H. & Li, Y.-X. (2017) Generation of an ASS1 heterozygous knockout human embryonic stem cell line, WAe001-A-13, using CRISPR/Cas9, Stem Cell Research. 26:67-71.
              

              4. Wu, F., Gao, G., Pan, T., Yang, Z., Xu, G., Abbas, N., Liu, Y., Chen, Y., Tan, S., You, K., Ke, X., Zhuang, Y., Lin, X., Yang, F. & Li, Y.-x. (2017) Generation of a SMO Homozygous Knockout Human Embryonic Stem Cell Line WAe001-A-16 by CRISPR/Cas9 Editing, Stem Cell Research. 27:5-9
              

              5. Lin, M., Xue, X. Y., Liang, S. Z., Li, Y. X., Lv, Y. Y., He, L. H., Xu, K. C., Zhang, L. F., Chen, J. B. & Niu, L. Z. (2017) MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6, Oncotarget. 8, 62914-62926
              

              6. Yuan, F., Guo, D., Gao, G., Liu, Y., Xu, Y., Wu, Y., Yang, F., Ke, X., Lai, K. & Li, Y.-x. (2017) Generation of a KCNJ11 homozygous knockout human embryonic stem cell line WAe001-A-12 using CRISPR/Cas9, Stem Cell Research. 24, 89-93. 
              

              7. Liu, Y., Wu, F., Zhuang, Y., Guo, D., Abbas, N., Wei, R., Wang, K., Chen, Y., Tao, J., Wu, Y., Yuan, F., Pan, T., Yang, F., Lai, K., Lai, L. & Li, Y.-x. (2017) Generation of three miR-122 knockout lines from a human embryonic stem cell line, Stem Cell Research.24, 164-168.
              

              8. Liu, Y., Ruzi, A., Guo, D., Wu, F., Liu, H., Wu, H., Wu, Y., Yuan, F., Zhuang, Y., Yang, F., Lai, K., Lai, L. & Li, Y.-x. (2017) Generation of two MEN1 knockout lines from a human embryonic stem cell line, Stem Cell Research. 24, 169-173.
              

              9. Liu, H., Guo, D., Ruzi, A., Chen, Y., Pan, T., Yang, F., Li, J., Xu, K., Zhou, T., Qin, D. & Li, Y. X. (2017) Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells, PLoS One. 12, e0179353. 
              

              10. Xu, Y., Wu, Y., Guo, D., Gao, G., Lai, K., Yang, F., Wang, K., Wu, H., Lai, L., Li, J., Xu, K. & Li, Y.-x. (2017) Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9, Stem Cell Research. 22, 29-32. 
              

              11. Li, Q., Hutchins, A. P., Chen, Y., Li, S., Shan, Y., Liao, B., Zheng, D., Shi, X., Li, Y., Chan, W.-Y., Pan, G., Wei, S., Shu, X. & Pei, D. (2017) A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes, Nature Communications. 8. 15166. 
              

              12. Guo, D., Liu, H., Ruzi, A., Gao, G., Nasir, A., Liu, Y., Yang, F., Wu, F., Xu, G. & Li, Y.-x. (2017) Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9, Scientific Reports. 7, 3156.
              

              13. Guo, D., Wu, F., Liu, H., Gao, G., Kou, S., Yang, F., Abbas, N., Zhou, T., Cai, X., Zhang, H., Qin, D., Li, J., Xu, K. & Li, Y.-x. (2017) Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome, Stem Cell Research. 18, 64-66. 
              

              14. Guo, D., Liu, H., Gao, G., Liu, Y., Zhuang, Y., Yang, F., Wang, K., Zhou, T., Qin, D., Hong, L., Li, J., Xu, K. & Li, Y.-x. (2017) Creating a patient carried Men1 gene point mutation on wild type iPSCs locus mediated by CRISPR/Cas9 and ssODN, Stem Cell Research. 18, 67-69.
              

              15. Guo, D., Wu, F., Liu, H., Gao, G., Kou, S., Yang, F., Abbas, N., Zhou, T., Cai, X., Zhang, H., Qin, D., Li, J., Xu, K. & Li, Y.-x. (2017) Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome, Stem Cell Research. 18, 70-72. 
              

              16. Guo, D., Liu, H., Gao, G., Ruzi, A., Wang, K., Wu, H., Lai, K., Liu, Y., Yang, F., Lai, L. & Li, Y.-x. (2016) Generation of an Abcc8 homozygous mutation human embryonic stem cell line using CRISPR/Cas9, Stem Cell Research. 17, 640-642. 
              

              17. Guo, D., Liu, H., Gao, G., Ruzi, A., Wang, K., Wu, H., Lai, K., Liu, Y., Yang, F., Lai, L. & Li, Y.-x. (2016) Generation of an Abcc8 heterozygous mutation human embryonic stem cell line using CRISPR/Cas9, Stem Cell Research. 17, 670-672. 
              

              18.Li Y-X, Zdanowicz M, Young L, Kumiski D, Leatherbury L and Kirby ML. Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function Development Dynamics. 226:540-550, 2003. PMID: 12619138
              

              19.Li Y-X, Kirby ML. Coordinated and conserved expression of alphoid repeat and alphoid repeat-tagged coding sequences. Developmental Dynamics 228(1):72-81, 2003. PMID: 12619138
              

              20.Wilkbanks AM, Fralish GB, Kirby ML, Barak LS, Li Y-X* and Caron MG.* Arrestin 2 regulates zebrafish development through the sonic hedgehog pathway. Science. 306:2264-2267, 2004. (*co-correspondence authors). PMID: 15618520
              

              21.Li YX*, Yang HT, Danowicz M, Sicklick JK, Qi Y, Camp T  and Diehl AM. Fetal Alcohol Exposure Impairs Hedgehog Cholesterol Modification and Signaling. Lab Invest. 87(3):231-40. 2007. (Presented as the Journal cover picture and with an Editorial Press Release) (* correspondence authors). PMID: 17237799.
              

              22.Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. Journal of Hepatology 48:98-106. 2008. PMID: 1802272. PMC2196213.
              

              23.Hua Mao H., Diehl AM., Li YX. Sonic Hedgehog Ligand Partners with Caveolin-1 for Intracellular Transportation. Lab Invest. 89:290-300. 2009. PMID: 19139721. PMC2647995
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              社會(huì )任職：
              
                            
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              獲獎及榮譽(yù)：
              
                            
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              · 1991 歐洲分子生物學(xué)訓練班學(xué)生獎，聯(lián)合國世界科教文組織
              

              · 1992美國衛生部國立衛生研究院 國際中心 博士后研究Forgarty獎
              

              · 1996中國國家科學(xué)技術(shù)進(jìn)步二等獎，衛生部，獎號：96202303
              

              · 1996中國國家最佳教育科技出版獎，教育部
              

              · 1999外藉最杰出科學(xué)教育人士，美國新聞總署 國家移民規劃局
              

              · 2005 杜克-斯特曼腫瘤及干細胞研究獎，杜克大學(xué)
              

              ·2004-2008美國心臟協(xié)會(huì )科研基金分子生物學(xué)和細胞生物學(xué)審批，主評委員
              

              ·2009美國國立衛生院（NIH）肝臟干細胞總統科學(xué)促進(jìn)計劃基金，Challenge Grant Panel 18 (ZRG1 DKUS A58, Liver stem cell study) 科學(xué)審批委員會(huì )委員
              

              ·2010美國國立衛生院(NIH)先天畸形及酒精致畸國家科研基金，Special Emphasis Panel (ZAA1DD 01, Alcohol Defect research center grant) 科學(xué)審批委員會(huì )委員
              

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              代表論著(zhù)：
              
                            
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