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            專(zhuān)家人才

            • 姓名: 彭廣敦
            • 性別: 男
            • 職稱(chēng): 研究員
            • 學(xué)歷: 
            • 電話(huà): 
            • 傳真: 
            • 電子郵件: peng_guangdun@gibh.ac.cn
            • 通訊地址 廣州市科學(xué)城開(kāi)源大道190號

              簡(jiǎn)歷:

            • 2009年博士畢業(yè)于中國科學(xué)院上海生物化學(xué)與細胞生物學(xué)研究所,美國加州大學(xué)洛杉磯分校(UCLA)博士后;回國后在中國科學(xué)院上海生物化學(xué)與細胞生物學(xué)先后擔任助理研究員、副研究員。20189月入職中國科學(xué)院廣州生物醫藥與健康研究院,擔任研究員、課題組長(cháng)、博士生導師。為國家高層次青年人才,廣東省杰青,細胞譜系與發(fā)育研究中心副主任。
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              研究領(lǐng)域:

            • “細胞學(xué)說(shuō)”指出“所有生命體皆由細胞組成”,“細胞是生命的基本單元”以及“所有細胞都由此前的細胞變化而來(lái)”等核心概念,成為現代生物學(xué)的重要基石。然而,細胞的類(lèi)型如何定義、細胞的過(guò)去現在和未來(lái)如何精確解碼—這些細胞的“譜系信息”在漫長(cháng)的科學(xué)研究長(cháng)河中,一直是科學(xué)中的重要和基本問(wèn)題并沒(méi)有得到很好的解答。捕獲細胞譜系的多維信息,尤其是探究其在時(shí)間、空間維度的精確動(dòng)態(tài)變化,是探索生命奧秘、解析發(fā)育程式、治愈疾病、延緩衰老的基礎;對細胞譜系的精準操控,是基于細胞治療、器官重建的未來(lái)再生醫學(xué)應用之不可或缺的前提。本實(shí)驗室圍繞細胞的時(shí)空動(dòng)態(tài)譜系問(wèn)題,主要開(kāi)展以下研究:

              研究方向一:?jiǎn)渭毎嘟M學(xué)與譜系示蹤技術(shù)解析細胞譜系的功能分群與異質(zhì)性

              結合單細胞多組學(xué)測序、單細胞譜系示蹤、生物信息學(xué)、人工智能以及類(lèi)器官等手段重點(diǎn)關(guān)注胚胎與組織中特定功能細胞的動(dòng)態(tài)變化與細胞譜系決定的調控機制。

              研究方向二:原位空間多組學(xué)技術(shù)解析空間功能特異的細胞調控特征

              發(fā)展和利用高通量、高分辨率的空間多組學(xué)技術(shù),研究組織功能實(shí)現的細胞基礎,揭示原位、動(dòng)態(tài)、多維度的細胞命運決定與調控網(wǎng)絡(luò )。

              研究方向三:新型多能干細胞用于體外器官重建與功能修復

              基于細胞譜系的新發(fā)現,實(shí)現譜系再造、損傷修復與器官的體外重建。

              主要學(xué)術(shù)成果

              聚焦細胞的時(shí)空動(dòng)態(tài)譜系研究,以技術(shù)與數據驅動(dòng)生物學(xué)新發(fā)現。開(kāi)發(fā)了多種空間組學(xué)原創(chuàng )技術(shù),繪制了小鼠著(zhù)床后胚胎三個(gè)胚層建立過(guò)程高分辨率的時(shí)空動(dòng)態(tài)分子圖譜,揭示了多能干細胞的發(fā)育調控網(wǎng)絡(luò ),解析了小鼠大腦的時(shí)空動(dòng)態(tài)譜系發(fā)育過(guò)程,發(fā)現了新型的組織干細胞可用于體外器官重建與組織修復。發(fā)表研究論文及綜述七十余篇,引用超過(guò)3000多次,通訊作者論文發(fā)表在Nature、Nature Methods、Nature Genetics、Annals of the Rheumatic Disease、Nature Communications、Cell Reports等,研究成果獲選“2019年度中國生命科學(xué)十大進(jìn)展、“2019年度中國生物信息學(xué)十大進(jìn)展“2019年度中國生物信息學(xué)十大應用”。

              承擔科研項目情況:

            • 中國科學(xué)院器官重建與制造”A類(lèi)戰略性先導科技專(zhuān)項

              國家重點(diǎn)研發(fā)計劃干細胞及轉化研究重點(diǎn)專(zhuān)項

              國家重點(diǎn)研發(fā)計劃“發(fā)育編程及其代謝調控”重點(diǎn)專(zhuān)項

              國家重點(diǎn)人才計劃高層次青年人才項目

              國家自然科學(xué)基金面上項目

              廣東省自然科學(xué)基金杰出青年項目

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              社會(huì )任職:

            • 國際干細胞學(xué)會(huì )(ISSCR)會(huì )員


              獲獎及榮譽(yù):

            • Sanofi-SIBS 2017 Distinguished Young Faculty????

              ISSCR 2017 Poster Award and Travel Award??

              國家級人才項目


              代表論著(zhù):

            • 2018-2024?

              1.?????? Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ, Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Ann Rheum Dis IF27

              2.?????? Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S*, Peng G* (2023) Three-dimensional molecular architecture of mouse organogenesis. Nat Commun, 14: 4599

              3.?????? Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K, Peng G* (2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods, 20: 1048–1057

              4.?????? Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*, Peng G*, Jing N* (2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. Cell Regen, 12: 15

              5.?????? Meng X, Cui G, Peng G* (2023) Lung development and regeneration: newly defined cell types and progenitor status. Cell Regen, 12: 5

              6.????? Chen C, Liao Y, Peng G* (2022) Connecting past and present: single-cell lineage tracing. Protein Cell

              7.?????? Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N*, Peng G* (2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Rep, 40: 111285

              8.?????? Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*, Peng G*, Ren X*, Jiang N*, Tian C*, Chen ZJ* (2022) Single-cell technologies: From research to application. Innovation (Camb), 3: 100342

              9.????? Li Z, Peng G (2021) Spatial transcriptomics: new dimension of understanding biological complexity. Biophysics Reports, 7: 1–17

              10.?? Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G*, Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Prolif, 54: e13000

              11.?? Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G*, Qiao Y* (2021) Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo. Cell Prolif, e13096

              12.??? Peng, G.*, Cui, G., Ke, J. and Jing, N. (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genomics Hum Genet 2020; 21 163-181.

              13.??? Peng G#*, Suo S#, Cui G#, Yu F#, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ*, Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature, 572: 528–532

              14.??? Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H*, Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet, 51: 728–738

              15.??? Cui, G., Jing, N. and Peng, G.* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo’. J Mol Cell Biol 11, 1024-1025.

              16.??? Peng G, Han JJ (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res, 7:

              17.??? Cui G, Suo S, Wang R, Qian Y, Han JJ*, Peng G*, Tam PPL*, Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ, 60: 463–472

              18.??? Han X#, Luo S#, Peng G#, Lu JY, Cui G, Liu L, Yan P, Yin Y, Liu W, Wang R, Zhang J, Ai S, Chang Z, Na J, He A, Jing N, Shen X (2018) Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. J Mol Cell Biol, 10: 175–178??

              2016-2018?

              19.??? Peng G (2017) Looking Back: Single-Cell Analysis Empowering Stem Cell Studies (2017) Cell Stem Cell 20: 758 (Commentary)

              20.??? Peng G, Tam PPL, Jing N (2017) Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies. National Science Review, 4: 533–542

              21.??? Peng G*, Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Sci China Life Sci, 60: 363–369

              22.??? Chen J#, Suo S#, Tam PP, Han JJ, Peng G*, Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nat Protoc, 12: 566–580

              23.??? Peng G#, Suo S#, Chen J#, Chen W, Liu C, Yu F, Wang R, Chen S, Sun N, Cui G, Song L, Tam PP, Han JD*, Jing N* (2016) Spatial transcriptome for the molecular annotation of lineage fates and cell identity in mid-gastrula mouse embryo. Dev Cell, 36: 681–697??

              (*: corresponding author; #: first author)

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              完整論文情況Google scholar: https://scholar.google.com/citations?user=s7XddBgAAAAJ